In designing an optimal American strategy toward the Middle East, two factors stand out. One is that now, as most always in the past, the climate of opinion is both “this is the last chance for peace” and “this is a time when nothing can be done”. The second is that whatever happens in the region at this point in the 21st century will affect and be affected by negative and dangerous new trends in the other power centers of the world: China, Russia, the U.S., and even the European Union.