The goal of the United States and its allies must be the total eradication of the Islamic State. Destroying ISIS begins with eliminating its self-styled caliphate in Iraq and Syria. This can be accomplished by arming local actors and assisting them with advisers, forward air control teams, and airpower. More importantly, the United States must work with regional partners to knit together a political solution to provide Iraqi and Syrian Sunni Arabs a measure of autonomy to prevent the reemergence of ISIS or its ideological successor. The United States must also wage a holistic campaign to combat ISIS elsewhere in the world. Means include pressuring ISIS affiliates through drone strikes and by strengthening partner states, using financial and legal means to impede terrorist financing, combating radicalization in cyberspace and on social media platforms, and focusing intelligence capabilities to uncover ISIS operatives seeking to conduct terror attacks in Europe and the United States.